Oddly shaped immune cells cause fibrosis


Oddly shaped immune cells cause fibrosis

Scientists at the Immunology Frontier Research Center (IFReC) at Osaka University, Japan, report a new group of monocytes they call SatM. Studies in mice show that SatM may be responsible for causing fibrosis and creates a new drug target for an ailment that has little effective therapies.

Fibrosis is a form of scarring that could if uncontrolled cause deleterious thickening of tissues. Although it is known that fibrosis is caused by an activated immune system, which specific cells are responsible continuous to elude researchers.

Scientists at IFReC may have found this subgroup, as they report in Nature a class of monocyte cells with strange morphology. "The cells had a bi-lobed segmented nuclear shape and many cytoplasmic granules. We therefore called them 'Segregated nucleus atypical monocytes (SatM)'," said IFReC Professor Shizuo Akira.

To identify this subgroup, the researchers looked at immune cell subpopulations that predominantly appeared in fibrosis. "These cells were regulated by C/EBPβ," observed Akira.

Detailed examination of immune cells showed that the C/EBPβ mutant mice, unlike normal mice, produced no SatM, whereas no other observed immune cell population was changed. The mice were also significantly more resistant to fibrosis. On the other hand, when the mutant mice were exposed to SatM, their susceptibility to fibrosis rose.

Although Dr.Akira, Dr. Satoh and his colleagues describe SatM as a subset of monocytes, SatM showed characteristics that suggested they were hybrids of different immune cells. According to Akira, gene analysis found SatM "showed granulocyte markers, but SatM are definitely not granulocytes. These cell type is one of monocyte."

Additional study found the progenitor cells responsible for producing SatM. Adoptive transfer of these progenitors into mutant mice unable to produce SatM resulted in a SatM population, and C/EBPβ was found to be essential for maintaining the progenitors.

The ability to isolate cells specifically related to fibrosis gives hope for new therapies.

"Decades of research have shown that immune cells are extremely diverse," said Akira. "Clear definitions of the subpopulations are essential for properly diagnosing and treating diseases. Our discovery of SatM should improve therapeutic strategies against fibrosis."



Add Comment

all comments

  Other news

more
Prince Carl Philip and Princess Sofia of Sweden are expecting their second baby!

Prince Carl Philip and Princess Sofia of Sweden are expecting their second baby!..

23-Mar, 13:18

Carl and Sofia are already parents to son Prince Alexander Last summer...

Report: Pakistan Terror Groups Get Rich From Crime, Money Laundering

Report: Pakistan Terror Groups Get Rich From Crime, Money Laundering..

23-Mar, 19:42

FILE - A Pakistani nun holds a candle during a vigil for victims of a...

Madonna posts cute photo of her adopted daughters sleeping

Madonna posts cute photo of her adopted daughters sleeping..

23-Mar, 22:20

by Emmy Griffiths Madonna has shared an adorable snap of her twins...

Devin Nunes apologises to Democrats for surveillance briefing

Devin Nunes apologises to Democrats for surveillance briefing..

23-Mar, 16:37

The chairman of the House intelligence committee has apologised for not...

Jobs Episode 1

Jobs Episode 1..

02-Mar, 22:12

The following Jobs Episode 1 English Sub has been released. Full HD Drama...

Gorbachev:

Gorbachev: "It all looks as if the world is preparing for war"..

28-Jan, 02:54

Former Soviet leader Mikhail Gorbachev has issued a dire warning: "The...

Mali-based extremists claim deadly attack on military base

Mali-based extremists claim deadly attack on military base..

10-Mar, 07:13

Mauritania's state-run news agency says a newly formed extremist group...

Every Question Episode 3878

Every Question Episode 3878..

09-Mar, 21:00

The following Every Question Episode 3878 English Sub has been released....